Space Ghost Coast to Coast was an animated talk show that featured several characters from the classic Hanna-Barbera series, Space Ghost. The series aired on both Cartoon Network and Adult Swim from 1994 to 2004. In 2006, GameTap began producing episodes of the series, with a total of 17 new episodes produced between 2006 and 2008. Coast to Coast was Cartoon Network's second original series, the first being The Moxy Show. However, it was the first series to be fully produced by Cartoon Network. The series was so successful that 5 spin-offs were produced: Cartoon Planet, The Brak Show, Harvey Birdman, Attorney at Law, Perfect Hair Forever and Adult Swim's longest running series Aqua Teen Hunger Force.
Retiring from being a superhero, Space Ghost decides to make a talk-show with the help of his enemies, Zorak and Moltar, and interviews real-life celebrities.