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- Young Justice premieres.
- The Powerpuff Girls is removed from Cartoon Network's schedule until December 31.
- Dexter's Laboratory is removed from Cartoon Network's schedule on March 4, 2011.
- Looney Tunes returns regularly on Cartoon Network after 14 months.
- Scaredy Squirrel premieres.
- Season Three of Star Wars: The Clone Wars ends.
- The logo turns upside down for April Fools Day 2011.
- The Problem Solverz premieres.
- A sneak peek of The Amazing World of Gumball premieres.
- The second half of season one of Scooby-Doo! Mystery Incoporated premieres on May 3, 2011.
- The Looney Tunes Show premieres on May 3, 2011.
- The Amazing World of Gumball premieres.
- Season Two of Adventure Time ends.
- Regular Show moves back to 8:15
- MAD moves back to 8:30
- On May 29, 2011 Cartoon Network introduces a new theme and slogan titled "YEEEAUHHHH!" though it did not replace the CHECK it era.
- Courage the Cowardly Dog is removed from Cartoon Network's schedule for the first time in five years until September 26.
- Sidekick and Almost Naked Animals premiere.
- After being on the channel for twelve years ( 6 or 10 years new episodes, and 2 years of reruns ), Ed, Edd n Eddy is removed from Cartoon Network's schedule until December 31.
- 2 Stupid Dogs returns to Cartoon Network for the first time in ten years.
- Season Three of Adventure Time premieres.
- Season one finale of Scooby-Doo! Mystery Incoporated air in July 26, 2011
- Thundercats 2011 air it's 1 hour premieres event on July 29, 2011
- Season Two of Regular Show ends.
- Season 3 of Regular Show premieres.
- Secret Mountain Fort Awesome was pushed from the next month's 3rd day to the 26th this month.
- Courage the Cowardly Dog returns after three months removed from Cartoon Network's schedule.
- Halloween themed bumpers from last year return for the holiday.
- Halloween bumpers end.
- Cartoon Network's schedule changes again, with Courage the Cowardly Dog being removed once again with reruns of The Amazing World of Gumball replacing its timeslot.
- Tom and Jerry Tales premieres.
- Level Up air as a pilot movie and it was greenlight as TV series.
- Tom and Jerry Food Fight airs for the twentieth time.
- Christmas themed bumpers from last year begin airing.
- Lego Ninjago: Masters of Spinjitzu air as a series premiere.